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No specific dose adjustment encouraged when tofacitinib coadministered with strong CYP2C19 inhibitors; lower tofacitinib dose if coadministered with equally moderate CYP3A4 and strong CYP2C19 inhibitors .Renal Impairment: Modafinil need to be applied with caution in individuals with severe renal impairment. Nonetheless, no suggestions for renal dos